Products
Outline of Magnetic Resonance Innovations, Inc.' Product and Service OfferingMagnetic Resonance Innovations, Inc. develops magnetic resonance imaging software products. It also provides R&D services to MRI manufacturers and software companies, and MRI expertise and tools to the pharmaceutical and biotechnology industry.
Products and services:
Imaging solutions for pharma and biotech companiesSWI software: currently commercialized worldwide through non-exclusive license with Siemens Medical Systems Post-processing Software Modules: currently working prototype modes tested at several sites; commercialization licensing agreement R&D services to support the innovation departments of hardware and software manufacturers using MRI CRO consulting to pharmaceutical and biotechnology companies to optimize their use of MRI for pre-clinical and clinical trials
We provide cutting-edge MRI solutions and expertise to pharmaceutical and biotechnology companies to optimize their pre-clinical and clinical trials. Specific services provided internally or with core partners, include:
Specifically, numerous peer-reviewed articles found Magnetic Resonance Innovations, Inc.' SWI product to provide enhanced contrast on major pathologies (see Appendix B). This can allow pharmaceutical companies to reach statistically significant results faster, whether for go/no-go decisions or for FDA submissions, thus accelerating their time-to-market. The average value of accelerated time-to-market is up to $25M per month (equivalent to the monthly revenues of an average pharmaceutical drug, captured by the pharmaceutical company thanks to an earlier market launch). Even more specifically, Magnetic Resonance Innovations, Inc. can assist pharmaceutical and biotechnology companies to develop, optimize and validate SWI-based imaging biomarkers as biomarkers, and possibly as surrogate clinical endpoints for clinical trials, in partnership with other sponsors. Finally, Magnetic Resonance Innovations, Inc. may provide some of the biomedical R&D services outlined above to medical research institutions.Protocol design and site training (possibly including SWI) Central lab (image collection, analysis, interpretation, reporting) Database and image transfer interface Tool for image visualization, processing, quantification
Outline of Product Portfolio Development Roadmap
| Module/Projects | Description | Applications |
| SWIM | Quantification of Magnetic Susceptibility | Measuring oxygen saturation in veins, measuring iron in tissue and in microbleeds for MS, TBI and dementia |
| SWI / MRA Overlays onto High Resolution SWI | Allows for simultaneous visualization of SWI and MRA images | Neurovascular disease |
| SWI Phase Correction | Significantly improves SWI processing | Broad neurovascular applications |
| MS Lesion Recognition in Phase Images | Complement to magnitude image evaluations | Superior visualization and analysis of MS lesions |
| Complex thresholding | Removes noise points | This processing makes phase images look more like conventional images for the Radiologist |
| DCE perfusion processing | T1 independent method to find contrast agent uptake and changes of vascular behavior after drug treatment | DCE PWI is important in the study of anti-angiogenic agents |
| DSC perfusion processing | Conventional hemodynamic maps plus FWHM maps and MRA/SWI overlays | PWI is important in the study of multiple sclerosis, stroke and tumors to name a few |
| Normalization Filter | Corrects for spatial variations in fields | Can correct high field data to improve results of MRAs |
| Vessel Wall Analysis | Allows for vessel wall detection along with established "black blood" methods for carotid artery visualization | Atherosclerosis and vascular disease |
| Black Hole Counting | Automated calculations of micro-bleeds | Significant diagnostic potential for trauma and aging |
| Liver Iron Analysis | Superior alternative to T2* method when iron content is high | Liver pathology in hemachromotosis |
Our Technology:
Our proprietary software can better process imaging data for:
"SWI / SWIM" Data ProcessingSusceptibility Weighted Imaging (SWI) Partial Fourier Processing High Field Normalization Noise Reduction
Our core product Susceptibility Weighted Imaging (SWI) and the processing of the same is a major new method for diagnostic imaging. It represents a new MRI acquisition and image processing method that exploits susceptibility differences between tissues. It produces an enhanced contrast magnitude image which is extremely sensitive to venous blood, hemorrhage and iron storage. Using proper processing of SWI data will lead to better diagnosis of disease by Radiologists.
All data collected using susceptibility weighted imaging methods need special processing. This includes using both magnitude and phase images and filtering the magnitude with the phase images. Further processing using minimum and maximum intensity projections will pull out valuable information about the brain's vasculature for better diagnosis of the data. Special processing of the phase data may also prove valuable for iron quantification.
An important final step in processing SWI filtered phase data, is to produce a susceptibility map. We refer to this final step as SWIM. The resulting SWIM images can be used to quantify iron, oxygen saturation, calcium and any other related susceptibility changes that occur in various tissues.
Clinical Applications:
Numerous peer-reviewed studies have shown the value of SWI to better analyze, understand and diagnose a number of key pathologies, including:
Plus the following less prevalent but important neurological diseasesTrauma Stroke and Hemorrhage Tumors, Including Visualizing Oxygen Saturation in Tumors Multiple Sclerosis Vascular Dementia and Cerebral Amyloid Angiopathy (CAA)
Occult Vascular Diseases (Cavernomas, Angiomas, Telangiectasias) Sturge-Weber Disease Differentiating Calcium from Veins Mineralization, Iron and Hemorrhage in the Basal Ganglia